Development of auto-antibodies Some cobalamin preparations in rare cases can stimulate an allergenic response where there is development of antibodies to the cobalmin injected
In general, three major systems help to protect host cells from oxidative and nitrosative stress: (1) the superoxidase dismutase (SOD) and catalase system, (2) the glutathione system and (3) the thioredoxin system
After having a B12 shot, a person should monitor for adverse symptoms and seek medical help if they experience: severe pain at the injection site mild diarrhea a swelling sensation in the body temporary itching of the skin In rare cases, a person may also be at risk of: pulmonary edema peripheral vascular thrombosis, which involves blood clots polycythemia vera, which is a type of blood cancer If anyone experiences difficulty breathing, hives, and swelling, they need emergency medical help
It is now being looked into for possible health benefits
Mechanistically, the mitogenic effect promoted by HGF in SVZ cells is dependent on the activation of the ERK pathway (Nicoleau et al., 2009)
